| Identification | Back Directory | [Name]
(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one | [CAS]
514-07-8 | [Synonyms]
Taraxeron
Tarxerone
Taraxera-14-ene-3-one
D-Friedoolean-14-en-3-one
27-Norolean-14-en-3-one,13-methyl-, (13a)-
27-Norolean-14-en-3-one, 13-methyl-, (13α)-
Taraxerone, 98%, from Adenophora tetraphylla(Thunb.)Fisch
(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one | [Molecular Formula]
C30H48O | [MDL Number]
MFCD03458694 | [MOL File]
514-07-8.mol | [Molecular Weight]
424.7 |
| Chemical Properties | Back Directory | [Melting point ]
241-243 °C | [Boiling point ]
488.3±44.0 °C(Predicted) | [density ]
1.01±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [color ]
White to off-white | [LogP]
10.480 (est) |
| Hazard Information | Back Directory | [Uses]
Taraxerone is isolated from Sedum sarmentosum. Taraxerone enhances effects on alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities with EC50 values of 512.42 and 500.16 μM, respectively[1]. | [Definition]
ChEBI: A natural product found in Cupania cinerea. | [in vivo]
Taraxerone significantly lowers the plasma alcohol and acetaldehyde concentrations in mice. Compare to the control group, the ADH and ALDH expressions in the liver tissues are abruptly increased in the taraxerone-treated groups after ethanol exposure[1].
Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease induced by ethanol administration[1]. | [References]
[1] Sung CK, et al. Taraxerone enhances alcohol oxidation via increases of alcohol dehyderogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities and gene expressions.Food Chem Toxicol. 2012 Jul;50(7):2508-14. DOI:10.1016/j.fct.2012.04.031 |
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