| Identification | Back Directory | [Name]
PEPSINOSTREPTIN | [CAS]
51724-57-3 | [Synonyms]
Pepsidin A
PEPSINOSTREPTIN
N-Isobutyrylpepstatin
Isobutyryl-Val-Val-Sta-Ala-Sta-OH
Isobutyryl-Val-Val-Sta-Ala-Sta (Sta = statine = (3S,4S)-4-Amino-3-hydroxy-6-methylheptanoic acid)
L-Alaninamide, N-(2-methyl-1-oxopropyl)-L-valyl-L-valyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]- | [Molecular Formula]
C33H61N5O9 | [MDL Number]
MFCD00214075 | [MOL File]
51724-57-3.mol | [Molecular Weight]
671.87 |
| Hazard Information | Back Directory | [Uses]
Pepsinostreptin is an enzyme inhibitor with the activity of inhibiting pepsin. Pepsinostreptin can form a 1:1 complex with pepsin and significantly inhibit its activity. The activity of pepsinostreptin makes it have important application potential in the study of protease inhibition and related biological processes[1]. | [Definition]
ChEBI: Pepsinostreptin is a peptide. | [Enzyme inhibitor]
This statin-containing peptidomimetic (FW = 670.87 g/mol)) Structure: Isobutyryl-L-Val-L-Val-Sta-L-Ala-Sta, where Sta is statine, or (3S,4S)-4- amino-3-hydroxy-6-methylheptanoic acid, from a stain of Streptomyces forms a high-affinity complex with pepsin, inhibiting its activity. Pepsinostreptin, which is identical to pepstatin A, except for the N-terminal isobutyryl group in place of pepstatin’s isovaleryl group, probably inhibits other aspartate proteinases | [References]
[1] Lower homologues of ahpatinin, aspartic protease inhibitors, from a marine Streptomyces sp DOI:10.1021/np500337m |
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