| Identification | Back Directory | [Name]
3-MATIDA | [CAS]
518357-51-2 | [Synonyms]
3-MATIDA
3 MATIDA,3MATIDA
α-Amino-5-carboxy-3-methyl-2-thiopheneaceticacid
2-Thiopheneacetic acid, α-amino-5-carboxy-3-methyl-
ALPHA-AMINO-5-CARBOXY-3-METHYL-2-THIOPHENEACETIC ACID
5-[amino(carboxy)methyl]-4-methylthiophene-2-carboxylic acid | [Molecular Formula]
C8H9NO4S | [MDL Number]
MFCD07783998 | [MOL File]
518357-51-2.mol | [Molecular Weight]
215.23 |
| Hazard Information | Back Directory | [Uses]
3-MATIDA is a potent mGluR-1 antagonist. | [Definition]
ChEBI: 5-[amino(carboxy)methyl]-4-methyl-2-thiophenecarboxylic acid is an alpha-amino acid. | [Biological Activity]
Potent metabotropic glutamate mGlu 1 receptor antagonist (IC 50 = 6.3 μ M at rat mGlu 1a ). Displays ≥ 40-fold selectivity over other receptors: mGlu 5 , mGlu 2 , mGlu 4a (IC 50 > 300 μ M), NMDA and AMPA (IC 50 = 250 μ M). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro . Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo . |
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