| Identification | Back Directory | [Name]
codeine phosphate | [CAS]
52-28-8 | [Synonyms]
Galcodine
Tricodein
Codicept Phosphate
Coducept Phosphate
CodeinePhosphate[D.D]
Codeine phosphate (1:1)
Phosphoric acid codeine
Codeine phosphate (6CI, 7CI)
Morphine 3-Methyl Ether Phosphate
(5a,6a)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methyl-morphinan-6-ol Phosphate
Morphinan-6-alpha-ol, 7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-, phosphate
Morphinan-6a-ol, 7,8-didehydro-4,5α-epoxy-3-methoxy-17-methyl-, phosphate (1:1) (salt) (8CI)
Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5α,6α)-, phosphate (1:1) (salt)
Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5.alpha.,6.alpha.)-, phosphate (1:1) (salt) | [EINECS(EC#)]
200-137-8 | [Molecular Formula]
C18H22NO6P | [MOL File]
52-28-8.mol | [Molecular Weight]
379.344 |
| Chemical Properties | Back Directory | [Appearance]
White to Off-White Solid | [Melting point ]
238-240°C | [storage temp. ]
Controlled Substance, -20°C Freezer | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
solid | [Stability:]
Stable, but light sensitive. | [Major Application]
pharmaceutical | [Contact allergens]
Codeine has been reported as an occupational sensitizer
in workers in the production of opium alkaloids.
Codeine has been responsible for fixed drug eruptions
or generalized dermatitis. Cross-sensitivity is expected
to morphine. | [EPA Substance Registry System]
Codeine phosphate (52-28-8) |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Solid | [Uses]
Present in opium from 0.7% to 2.5%, depending on the source. Weak narcotic analgesic, perhaps due to conversion to morphine, with minimal hypnotic properties; potent antitussive.
Controlled substance (opiate) | [General Description]
Colorless small crystals or white powder. Odorless. Bitter taste. Solutions are acid to litmus. pH (4% solution) 4.2-5. | [Air & Water Reactions]
Water soluble. | [Reactivity Profile]
codeine phosphate is sensitive to exposure to light. . Materials that are acidic salts are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. | [Fire Hazard]
Flash point data for codeine phosphate are not available; however, codeine phosphate is probably combustible. | [Brand name]
Ambenyl
Cough Syrup (Parke-Davis); Colrex Compound (Solvay
Pharmaceuticals). |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral |
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