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520-42-3

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520-42-3 Structure

520-42-3 Structure
IdentificationBack Directory
[Name]

asebogenin
[CAS]

520-42-3
[Synonyms]

asebogenin
4'-O-Methylphloretin
1-(2,6-Dihydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-1-propanone
1-Propanone, 1-(2,6-dihydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-
[Molecular Formula]

C16H16O5
[MDL Number]

MFCD00017397
[MOL File]

520-42-3.mol
[Molecular Weight]

288.3
Chemical PropertiesBack Directory
[Melting point ]

168℃
[Boiling point ]

550.9±50.0 °C(Predicted)
[density ]

1.325±0.06 g/cm3(Predicted)
[pka]

7.00±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

Asebogenin has antimalarial activity in vitro[1]. Asebogenin can inhibit the phosphorylation of Syk, thereby effectively suppressing platelet activation and the formation of neutrophil extracellular traps[2].
[Definition]

ChEBI: A member of the class of dihydrochalcones that is the 4'-methyl ether derivative of phloretin.
[References]

[1] 1.Jenett-Siems K, et al. n vitro antiplasmodial activity of Central American medicinal plants. Trop Med Int Health. 1999 Sep;4(9):611-5. DOI:10.1046/j.1365-3156.1999.00456.x
[2] Li L, et al. Asebogenin suppresses thrombus formation via inhibition of Syk phosphorylation. Br J Pharmacol. 2023 Feb;180(3):287-307. DOI:10.1111/bph.15964
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