| Identification | Back Directory | [Name]
acronycidine | [CAS]
521-43-7 | [Synonyms]
acronycidine
5,7,8-Trimethoxydictamnine | [Molecular Formula]
C15H15NO5 | [MDL Number]
MFCD01725568 | [MOL File]
521-43-7.mol | [Molecular Weight]
289.28 |
| Chemical Properties | Back Directory | [Melting point ]
136.5-137.5 °C(Solv: methanol (67-56-1)) | [Boiling point ]
446.0±40.0 °C(Predicted) | [density ]
1.259±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
A powder | [pka]
7.80±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Acronycidine is a quinoline alkaloid with antimalarial activity and can be extracted from Acronychia baueri Schott. Acronycidine can be utilized in malari research[1][2]. | [Definition]
ChEBI: Acronycidine is a quinoline alkaloid that is furo[2,3-b]quinoline bearing four methoxy substituents at positions 4, 5, 7 and 8. It has a role as a plant metabolite. It is a quinoline alkaloid, an aromatic ether and a furoquinoline. | [Biological Activity]
5,7,8-Trimethoxydictamnine is a quinoline alkaloid that has been found in Rutaceae and has antimalarial activity.1 It is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50s =19.9 and 5.72 μg/ml, respectively). | [References]
1.Basco, L.K.M., S., Skaltsounis, A.-L., Ravvelomanantsoa, N., et al.In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparumAntimicrob. Agents Chemother.38(5)1169-1171(1994)
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