| Identification | Back Directory | [Name]
FOSFESTROL | [CAS]
522-40-7 | [Synonyms]
FOSFESTROL
DIETHYLSTILBOESTROLDIPHOSPHATE
DIETHYLSTILBESTROL DIPHOSPHATE
diethylstilbestrol bisphosphate
diethylstilbesterol diphosphate
stilboestrol bis(dihydrogen phosphate)
3-Hexene-3,4-diylbis(4,1-phenylene) bis[dihydrogen (phosphate)]
(E)-Hex-3-ene-3,4-diylbis(4,1-phenylene) bis(dihydrogen phosphate)
alpha,alpha'-diethyl-(e)-4,4'-stilbenediol bis(dihydrogen phosphate)
alpha,alpha'-diethyl-, bis(dihydrogen phosphate), (e)-4'-stilbenediol
[4-[(E)-4-(4-phosphonooxyphenyl)hex-3-en-3-yl]phenyl] dihydrogen phosphate
Phenol, 4,4'-[(1E)-1,2-diethyl-1,2-ethenediyl]bis-, 1,1'-bis(dihydrogen phosphate) | [EINECS(EC#)]
208-328-8 | [Molecular Formula]
C18H22O8P2 | [MDL Number]
MFCD00867397 | [MOL File]
522-40-7.mol | [Molecular Weight]
428.31 |
| Hazard Information | Back Directory | [Originator]
Stilphostrol,Dome,US,1955
| [Uses]
Diethylstilbestrol Diphosphate USP (Stilphostrol) is used to treat Prostatic carcinoma. | [Definition]
ChEBI: Diethylstilbestrol diphosphate is an aryl phosphate. It is functionally related to a diethylstilbestrol. | [Manufacturing Process]
A solution of 1 part of α,α'-diethyl-4,4'-dihydroxystilbene in 5 parts of pyridine
is added drop by drop to the strongly cooled solution of 2 parts of
phosphorus-hydroxy chloride in 5 parts of pyridine. The mixture soon solidifies
to a crystalline magma. It is allowed to stand in ice for ? hour and then for
an hour at room temperature. The mass is then poured into an excess of
saturated sodium bicarbonate solution. Unconsumed parent material is
removed by extraction with ether. The aqueous solution is then mixed with 2
N hydrochloric acid, whereupon the primary phosphoric acid ester of α,α'-
diethyl-4,4'-dihydroxystilbene of the formula is precipitated in the form of a
voluminous white powder. By recrystallization or reprecipitation this ester may
be further purified.
| [Therapeutic Function]
Estrogen, Antitumor | [General Description]
Odorless off-white crystalline powder. | [Air & Water Reactions]
Insoluble in water. | [Reactivity Profile]
Organophosphates, such as FOSFESTROL, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. | [Fire Hazard]
Flash point data for FOSFESTROL are not available; however, FOSFESTROL is probably combustible. |
|
| Company Name: |
AFINE CHEMICALS LIMITED
|
| Telephone: |
+86-571-85134551 +86-18958018566 |
| Website: |
www.afinechem.com/index.html |
| Company Name: |
Shaanxi Dideu Medichem Co. Ltd
|
| Telephone: |
+86-29-87569266 +86-17392581500 |
| Website: |
https://www.chemicalbook.com/manufacturer/shaanxi-dideu-medichem-220/ |
|