| Identification | Back Directory | [Name]
5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate | [CAS]
52248-03-0 | [Synonyms]
VHPOFDUCFKOUHV-XKGORWRGSA-O
P-toluenesulfonic acid adenosylmethionine
P-toluenesulfonic acid adenosylmethionine (SAMe)
S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt
5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate
5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate
S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt >=80% (HPLC), >=80% (spectrophotometric assay)
((S)-3-Amino-3-carboxypropyl)(((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonium 4-methylbenzenesulfonate | [Molecular Formula]
C22H30N6O8S2 | [MDL Number]
MFCD00063498 | [MOL File]
52248-03-0.mol | [Molecular Weight]
570.64 |
| Chemical Properties | Back Directory | [Melting point ]
78℃ | [storage temp. ]
-20°C | [solubility ]
DMF: 5 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid | [color ]
White to yellow | [biological source]
synthetic (Organic) | [Water Solubility ]
H2O: 100mg/mL |
| Hazard Information | Back Directory | [Uses]
S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt has been used for cell proliferation assay. It has also been used for methylation assay. | [General Description]
S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt is used for the treatment of depression, liver cirrhosis, cholestasis and degenerative joint disease. | [Biochem/physiol Actions]
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury. | [in vivo]
Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC).? However, injury and HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health and prevent injury and HCC[3]. | [IC 50]
Human Endogenous Metabolite |
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