| Identification | Back Directory | [Name]
4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate | [CAS]
522649-59-8 | [Synonyms]
Malic Enzyme inhibitor ME1
2,5-Pyrrolidinedione, 3-[4-(4-hydroxyphenyl)-1-piperazinyl]-1-phenyl-
4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate | [Molecular Formula]
C20H21N3O3 | [MDL Number]
MFCD03453758 | [MOL File]
522649-59-8.mol | [Molecular Weight]
351.4 |
| Chemical Properties | Back Directory | [Boiling point ]
638.1±55.0 °C(Predicted) | [density ]
1.342±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 125 mg/mL (355.72 mM) | [form ]
Solid | [pka]
12.18±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM[1][2]. | [Biological Activity]
Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent malic enzyme (ME1) inhibitor with IC50 of 0.15 μM. | [in vitro]
Malic enzyme inhibitor ME1 (ME1; ME1*) (50 μM; 72 hours) shows a significant reduction in total cell numbers.
It shows a significant reduction in cell viability/metabolic activity in MTS cell.
It dose-dependently reduces the number of colonies formed by both HCT116 and HT29 cells.
Cell Viability Assay | Cell Line: | HCT116 and HT29 cell line | | Concentration: | 50 μM | | Incubation Time: | 72 hours | | Result: | Showed a significant reduction in total cell numbers. | | [target]
IC50: 0.15 μM (Malic enzyme) | [storage]
Store at -20°C | [References]
[1] Zhang YJ, et al. In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors. Bioorg Med Chem Lett. 2006 Feb;16(3):525-8. Epub 2005 Nov 8. DOI:10.1016/j.bmcl.2005.10.065
[2] Fernandes L, et al. Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice. Sci Rep. 2018 Sep 24;8(1):14268. DOI:10.1038/s41598-018-32532-w |
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