| Identification | Back Directory | [Name]
S-(hydrogen malonyl)coenzyme A | [CAS]
524-14-1 | [Synonyms]
malony-coa
Malonyl-CoA
Malonyl Coenzyme A
S-(Carboxyacetyl)coenzyme A
S-(hydrogen malonyl)coenzyme A
Coenzyme A, S-(hydrogen propanedioate)
coenzyme A malonyl derivative, tetralithium salt
Adenosine 5'-[diphosphoric acid β-[(R)-4-[[2-[[2-(carboxyacetylthio)ethyl]carbamoyl]ethyl]amino]-4-oxo-3-hydroxy-2,2-dimethylbutyl]]3'-phosphoric acid
3-[2-[3-[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]aminopropanoylamino]ethylsulfanyl]-3-oxo-propanoic acid | [EINECS(EC#)]
208-353-4 | [Molecular Formula]
C24H38N7O19P3S | [MDL Number]
MFCD00870167 | [MOL File]
524-14-1.mol | [Molecular Weight]
853.58 |
| Hazard Information | Back Directory | [Definition]
ChEBI: The S-malonyl derivative of coenzyme A. | [Uses]
Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1[1][2]. | [IC 50]
Human Endogenous Metabolite | [References]
[1] Folmes CD, et L. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovasc Res. 2007 Jan 15;73(2):278-87. DOI:10.1016/j.cardiores.2006.10.008
[2] Thupari JN, et al. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun. 2001 Jul 13;285(2):217-23. DOI:10.1006/bbrc.2001.5146
[3] Zammit VA. Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro. Biochem J. 1983 Mar 15;210(3):953-6. DOI:10.1042/bj2100953 |
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