| Identification | Back Directory | [Name]
FRAXIN | [CAS]
524-30-1 | [Synonyms]
FRAXIN
Paviin
FRAXIN(P)
Fraxoside
FRAXIN WITH HPLC
FRAXIN USP/EP/BP
Fraxin (Fraxoside
Fraxetol8-glucoside
FRAXETIN-8-GLUCOSIDE
FRAXETIN-8-O-GLUCOSIDE
Fraxetin 8-β-D-glucopyranoside
Fraxin, 98%, from Fraxinus chinensis Roxb.
7,8-Dihydroxy-6-methoxycoumarin 8-β-D-glucopyranoside
7,8-DIHYDROXY-6-METHOXYCOUMARIN-BETA-D-GLUCOPYRANOSIDE
7,8-DIHYDROXY-6-METHOXYCOUMARIN-beta-D-GLUCOPYRANOSIDE hplc
7-Hydroxy-6-methoxy-2-oxo-2H-chromen-8-yl beta-D-glucopyranoside
6-Methoxy-7-hydroxy-8-(β-D-glucopyranosyloxy)-2H-1-benzopyran-2-one
8-(β-D-Glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one
2H-1-Benzopyran-2-one, 8-(β-D-glucopyranosyloxy)-7-hydroxy-6-methoxy-
8-(β-D-Glucopyranosyloxy)-7-hydroxy-6-methoxycoumarin monohydrate
8-(beta-D-glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one
7-Hydroxy-6-methoxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
7-hydroxy-6-methoxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
7,8-Dihydroxy-6-methoxycoumarin 8-β-D-glucopyranoside, 8-(β-D-Glucopyranosyloxy)-7-hydroxy-6-methoxycoumarin | [EINECS(EC#)]
208-355-5 | [Molecular Formula]
C16H18O10 | [MDL Number]
MFCD00010093 | [MOL File]
524-30-1.mol | [Molecular Weight]
370.31 |
| Chemical Properties | Back Directory | [Melting point ]
205-208°C | [Boiling point ]
420.23°C (rough estimate) | [density ]
1.4066 (rough estimate) | [refractive index ]
1.5376 (estimate) | [storage temp. ]
2-8°C | [solubility ]
DMSO : 250 mg/mL (675.11 mM; Need ultrasonic) | [form ]
neat | [pka]
6.99±0.20(Predicted) | [color ]
White | [InChI]
InChI=1/C16H18O10/c1-23-7-4-6-2-3-9(18)25-14(6)15(11(7)20)26-16-13(22)12(21)10(19)8(5-17)24-16/h2-4,8,10,12-13,16-17,19-22H,5H2,1H3/t8-,10-,12+,13-,16+/s3 | [InChIKey]
CRSFLLTWRCYNNX-JAAAIXMONA-N | [SMILES]
C12OC(=O)C=CC=1C=C(OC)C(O)=C2O[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O |&1:15,16,18,19,21,r| | [LogP]
-1.930 (est) |
| Hazard Information | Back Directory | [Chemical Properties]
It is slightly soluble in cold water, easily soluble in hot water and hot ethanol, and practically insoluble in ether. It comes from the dried bark of the Fraxinus chinensis, Fraxinus truncatus, or Fraxinus styracifolius. | [Uses]
food and beverages | [Definition]
ChEBI: Fraxin is a beta-D-glucoside that is fraxetin attached to a beta-D-glucopyranosyl group at position 8 via a glycosidic linkage. It is a natural product isolated from the leaves of Fraxinus excelsior and exhibits potent hepatoprotective effects in vitro and in vivo. It has a role as a plant metabolite, an anti-inflammatory agent and a hepatoprotective agent. It is a beta-D-glucoside, a hydroxycoumarin and an aromatic ether. It is functionally related to a fraxetin. | [in vivo]
Fraxin (50 mg/kg, p.o.) significantly blocks the CCl4-induced elevation of ALT and AST. Fraxin (10 and 50 mg/kg, p.o.) significantly reduces the GSSG levels (1.7±0.3 and 1.5±0.2 nM/g liver, respectively) compared with the GSSG levels of the CCl4-treated group[1]. |
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