| Identification | Back Directory | [Name]
Naphtho[1,2-b]furan-4,5-dione, 2,3-dihydro-2,2-dimethyl- | [CAS]
52436-88-1 | [Synonyms]
Naphtho[1,2-b]furan-4,5-dione, 2,3-dihydro-2,2-dimethyl- | [Molecular Formula]
C14H12O3 | [MOL File]
52436-88-1.mol | [Molecular Weight]
228.24 |
| Chemical Properties | Back Directory | [Melting point ]
170-171 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3)) | [Boiling point ]
367.1±42.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) |
| Hazard Information | Back Directory | [Description]
beta-nor-Lapachone functions as an antibiofilm agent and adjuvant on the antifungal therapy related to resistant infections caused by C. glabrata. | [Uses]
β-Nor-lapachone is a Candida glabrata antibiofilm agent. β-Nor-lapachone can stimulate ROS production, inhibits efflux activity, adhesion, biofilm formation and the metabolism of mature biofilms of Candida glabrata. β-Nor-lapachone has antifungal activity[1]. | [References]
[1] Clemente de Moraes D, et al. Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata. Bioorg Med Chem. 2022;63:116749. DOI:10.1016/j.bmc.2022.116749 |
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