| Chemical Properties | Back Directory | [Boiling point ]
301.1±37.0 °C(Predicted) | [density ]
1.204±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.07±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model[1]. S-1-Propenyl-L-cysteine exhibits antioxidative efficacy through a NO-dependent BACH1 signaling pathway[2]. S-1-Propenyl-L-cysteine is orally active. | [in vivo]
S-1-Propenyl-L-cysteine (6.5 mg/kg, p.o.) reduces systolic blood pressure (SBP), alters histidine metabolism and exerts the antihypertensive effect via the central histamine H3 receptor in spontaneously hypertensive rats[3]. | Animal Model: | spontaneously hypertensive rats (SHR) [3] | | Dosage: | 6.5? mg/kg | | Administration: | p.o., single dosage | | Result: | Reduced blood pressure and produced a change in metabolites.
Increased histidine levels after 1.5-3 h after administration.
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| [References]
[1] Kodera Y, et al. Chemical and Biological Properties of S-1-Propenyl-l-Cysteine in Aged Garlic Extract. Molecules. 2017 Mar 31;22(4). DOI:10.3390/molecules22040570
[2] Tsuneyoshi T, et al., S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells. Nitric Oxide. 2019 Mar 1;84:22-29. DOI:10.1016/j.niox.2019.01.003
[3] Matsutomo T, et al., Metabolomic study reveals the acute hypotensive effect of S-1-propenylcysteine accompanied by alteration of the plasma histidine level in spontaneously hypertensive rats. J Pharm Biomed Anal. 2019 May 10;168:148-154. DOI:10.1016/j.jpba.2019.01.043
[4] Suzuki JI, et al., Anti-inflammatory action of cysteine derivative S-1-propenylcysteine by inducing MyD88 degradation. Sci Rep. 2018 Sep 20;8(1):14148. DOI:10.1038/s41598-018-32431-0 |
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