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Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal cord trauma[1][2][3]. | [in vivo]
Z-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats[2]. | Animal Model: | Male Wistar albino rats (250-350 g) with SCI[2] | | Dosage: | 0.8 μmol/kg | | Administration: | I.v. for 1 or 7 days | | Result: | Decreased the mean apoptotic cell count at 24 hours and 7 days postinjury. |
| [IC 50]
Caspase-9 | [storage]
Store at -20°C | [References]
[1] Ozoren N, et, al. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res. 2000 Nov 15; 60(22): 6259-65. PMID:11103780
[2] Colak A, et, al. Neuroprotection and functional recovery after application of the caspase-9 inhibitor z-LEHD-fmk in a rat model of traumatic spinal cord injury. J Neurosurg Spine. 2005 Mar; 2(3): 327-34. DOI:10.3171/spi.2005.2.3.0327
[3] Mocanu MM, et, al. Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. Br J Pharmacol. 2000 May; 130(2): 197-200. DOI:10.1038/sj.bjp.0703336 |
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