| Identification | Back Directory | [Name]
phellamurin | [CAS]
52589-11-4 | [Synonyms]
phellamurin
(dihydro) Phellodendron
(2R)-7-(β-D-Glucopyranosyloxy)-2,3-dihydro-3β,5-dihydroxy-2α-(4-hydroxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one,7-(b-D-glucopyranosyloxy)-2,3-dihydro-3,5-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-,(2R,3R)-
4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-2,3-dihydro-3,5-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-, (2R,3R)- | [Molecular Formula]
C26H30O11 | [MOL File]
52589-11-4.mol | [Molecular Weight]
518.52 |
| Chemical Properties | Back Directory | [Boiling point ]
861.5±65.0 °C(Predicted) | [density ]
1.504±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
7.15±0.60(Predicted) | [color ]
Light yellow to yellow | [biological source]
plant | [Water Solubility ]
water: slightly soluble |
| Hazard Information | Back Directory | [Uses]
Phellamurin is a natural product derived from plant source th at finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research. | [Definition]
ChEBI: A member of the class of dihydroflavonols that is (+)-dihydrokaempferol substituted by a prenyl group at position 8 and a beta-D-glucopyranosyl group at position 7 via a glycosidic linkage. Isolated from Phellodend
on amurense and Commiphora africana, it exhibits inhibition of intestinal P-glycoprotein. | [Biological Activity]
Phellamurin induces cells apoptosishas anti-tumor activityexhibits inhibition of intestinal P-glycoprotein and it has a role as a metabolite. | [in vivo]
Phellamurin (50?mg/kg/day; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment represses osteosarcoma tumor growth in vivo. The ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR are decreased in xenograft in Phellamurin-treated mice[1]. | Animal Model: | Athymic female BALB/c nude mice (6 weeks old ) injected with U2OS cells[1] | | Dosage: | 50?mg/kg/day | | Administration: | Intraperitoneal injection; daily; for 21 days | | Result: | Repressed osteosarcoma tumor growth in vivo.
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| [target]
P-gp |
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| Company Name: |
BioBioPha Co., Ltd.
|
| Tel: |
0871-65217109 13211707573; |
| Website: |
http://www.biobiopha.com |
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