| Identification | Back Directory | [Name]
PROSTAGLANDIN H1 | [CAS]
52589-22-7 | [Synonyms]
PGH1
PGR1
GPR153
Prostaglandin R1
PROSTAGLANDIN H1
Prostaglandin?H1?(PGH1)
NTAYABHEVAQSJS-ZKEWMDECSA-N
G-protein coupled receptor PGR1
Probable G-protein coupled receptor 153
(13E,15S)-9α,11α-Epidioxy-15-hydroxyprost-13-en-1-oic acid
9ALPHA,11ALPHA-EPIDIOXY-15S-HYDROXY-PROST-13E-EN-1-OIC ACID
9,11-epi-Dioxy-15-hydroxy-(9α,11α,13E,15S)-prost-13-en-1-oic acid
Prost-13-en-1-oic acid, 9,11-epidioxy-15-hydroxy-, (9α,11α,13E,15S)-
PROST-13-EN-1-OIC, 9,11-EPIDIOXY-15-HYDROXY-, (9ALPHA,11ALPHA,13E,15S)
PGH1, 9,11-epi-Dioxy-15-hydroxy-(9α,11α,13E,15S)-prost-13-en-1-oic acid | [Molecular Formula]
C20H34O5 | [MDL Number]
MFCD00084825 | [MOL File]
52589-22-7.mol | [Molecular Weight]
354.48 |
| Chemical Properties | Back Directory | [Boiling point ]
486.2±38.0 °C(Predicted) | [density ]
1.113±0.06 g/cm3(Predicted) | [Fp ]
-17 °C | [storage temp. ]
−70°C | [solubility ]
Ethanol: >100 mg/ml; PBS pH 7.2: >2 mg/ml | [form ]
acetone solution | [pka]
4.78±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Prostaglandin H1 (PGH1) is the unstable precursor to all 1-series PGs and thromboxanes.1,2,3 It is produced from dihomo-γ-linolenic acid (DGLA; Item No. 90230) by COX-1 and COX-2. 4,2 PGH1 is an agonist of the PGD2 receptor CRTH2.5 It increases intracellular calcium levels in HEK293 cells expressing CRTH2 when used at a concentration of 3 µM and induces CRTH2 internalization at 1 µM, an effect that can be blocked by the CRTH2 antagonist TM30089 (CAY10471; Item No. 10006735). PGH1 is also a suicide inhibitor of platelet thromboxane synthase (Ki = 28 µM).6WARNING This product is not for human or veterinary use. | [Definition]
ChEBI: Prostaglandin H1 is a member of the class of prostaglandins H that is prostaglandin H2 lacking the double bond at position 5. It has a role as a human xenobiotic metabolite. It is a prostaglandins H, an oxylipin, a bridged compound, an olefinic compound, an organic peroxide and a secondary alcohol. It is a conjugate acid of a prostaglandin H1(1-). |
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