| Identification | Back Directory | [Name]
5-Bromo-2,3-dimethoxypyridine | [CAS]
52605-98-8 | [Synonyms]
5-Bromo-2,3-dimethoxypyridine
Pyridine, 5-bromo-2,3-dimethoxy-
5-Bromo-2,3-dimethoxypyridine ISO 9001：2015 REACH | [Molecular Formula]
C7H8BrNO2 | [MDL Number]
MFCD11052853 | [MOL File]
52605-98-8.mol | [Molecular Weight]
218.05 |
| Chemical Properties | Back Directory | [Boiling point ]
222.7±35.0 °C(Predicted) | [density ]
1.484±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
solid | [pka]
2.19±0.10(Predicted) | [Appearance]
Colorless to off-white <32°C Solid,>32°C Liquid |
| Hazard Information | Back Directory | [Synthesis]
As shown in Step 2-iv of Scheme 2, a methanolic solution of 2,5-dibromo-3-methoxypyridine (13.0 g, 43.8 mmol) and 25 wt% sodium methanolate (95.0 mL, 438.3 mmol) was placed in a reaction vial and the reaction was stirred for 3 hours at 75 °C. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently extracted by adding ethyl acetate and saturated saline. The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford 5-bromo-2,3-dimethoxypyridine (9.1 g, 95% yield). The product was characterized as follows: ESMS (M + 1) = 218/220; 1H NMR (DMSO-d6) δ 7.8 (d, 1H), 7.46 (d, 1H), 3.81 (s, 3H), 3.86 (s, 3H). | [References]
[1] Patent: US2011/81316, 2011, A1. Location in patent: Page/Page column 14; 15 |
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| Company Name: |
Tetranov Biopharm
|
| Tel: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
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