| Identification | Back Directory | [Name]
galgravin | [CAS]
528-63-2 | [Synonyms]
galgravin
galgravin USP/EP/BP
inhibit,Inhibitor,Apoptosis,Galgravin
(2S,3S,4R,5R)-2,5-bis(3,4-dimethoxyphenyl)-3,4-dimethyloxolane
Furan, 2,5-bis(3,4-dimethoxyphenyl)tetrahydro-3,4-dimethyl-, (2R,3R,4S,5S)-rel- | [Molecular Formula]
C22H28O5 | [MDL Number]
MFCD30723086 | [MOL File]
528-63-2.mol | [Molecular Weight]
372.45 |
| Chemical Properties | Back Directory | [Melting point ]
139-140 °C(Solv: methanol (67-56-1)) | [Boiling point ]
479.1±45.0 °C(Predicted) | [density ]
1.082±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: soluble; DMSO: soluble | [form ]
A solid |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Heather vine. | [Uses]
Galgravin is an active compound in Nectandra megapotamica, with anti-inflammatory activity. Galgravin displays in vitro cytotoxic activity and induce apoptosis in leukemia cells[1][2]. | [Definition]
ChEBI: Galgravin is a member of the class of aryltetrahydrofurans carrying two 3,4-dimethoxyphenyl substituents at positions 2 and 5 as well as two methyl groups at positions 3 and 4. It has a role as a bone density conservation agent, a neuroprotective agent, a platelet aggregation inhibitor and a plant metabolite. It is an aryltetrahydrofuran, a dimethoxybenzene, a ring assembly and a lignan. | [References]
[1] da Silva Filho AA, et al. Evaluation of analgesic and anti-inflammatory activities of Nectandra megapotamica (Lauraceae) in mice and rats. J Pharm Pharmacol. 2004 Sep;56(9):1179-84. DOI:10.1211/0022357044058
[2] Ponci V, et al. Neolignans from Nectandra megapotamica (Lauraceae) Display in vitro Cytotoxic Activity and Induce Apoptosis in Leukemia Cells. Molecules. 2015 Jul 15;20(7):12757-68. DOI:10.3390/molecules200712757 |
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