| Identification | Back Directory | [Name]
Zoloperone | [CAS]
52867-74-0 | [Synonyms]
LR 511
Zoloperone
Zoloperonum
4-(4-Fluorophenyl)-5-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]oxazol-2(3H)-one
4-(4-fluorophenyl)-5-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)oxazol-2(3H)-one
4-(4-Fluorophenyl)-5-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-4-oxazolin-2-one
2(3H)-Oxazolone, 4-(4-fluorophenyl)-5-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]- | [Molecular Formula]
C22H24FN3O3 | [MDL Number]
MFCD00867751 | [MOL File]
52867-74-0.mol | [Molecular Weight]
397.448 |
| Hazard Information | Back Directory | [Originator]
Zoloperone,ZYF Pharm Chemical | [Manufacturing Process]
To 20% solution of phosgene in toluene, agitated and cooled to 0°C, are
added over 30 min a solution of 1-p-fluoro-benzoyl-1-hydroxy-3-N-[N'-(2-
methoxyphenyl)]piperazinopropane and triethylamine in anhydrous
chloroform. It is agitated at ambient temperature for 5 h, cooled to 0°C and
the solution saturated with gaseous ammonia. The solution is agitated at
ambient temperature for 3 h, filtered and the filtrate dried under reduced
pressure, 4-ρ-fluorophenyl-5-β-(4-o-methoxyphenylpiperazino)ethyl-4-
oxazolin-2-one, melting point 154°C (by alcohol) was obtained. | [Therapeutic Function]
Neuroleptic |
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