| Identification | Back Directory | [Name]
1,4-Pentanediamine, N4-[7-chloro-2-[(1E)-2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl- | [CAS]
529507-84-4 | [Synonyms]
1,4-Pentanediamine, N4-[7-chloro-2-[(1E)-2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl- | [Molecular Formula]
C26H31Cl2N3 | [MOL File]
529507-84-4.mol | [Molecular Weight]
456.45 |
| Chemical Properties | Back Directory | [Boiling point ]
597.1±50.0 °C(Predicted) | [density ]
1.191±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 10mg/mL, clear | [form ]
powder | [pka]
10.47±0.25(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
(E)-Aminoquinol (XIB4035) is a GFRα-1 agonist. (E)-Aminoquinol has mimic neurotrophic effects of GDNF, and induces Ret autophosphorylation in Neuro-2A cells. (E)-Aminoquinol can be used for research of Parkinson’s disease[1]. | [Biological Activity]
XIB4035 is a reported agonist of the glial cell-line derived neurotrophic factor (GDNF) receptor GFRα1. XIB4035 induces GFRα1/RET phosphorylation in Neuro2A cells. | [References]
[1] Tokugawa K, et al. XIB4035, a novel nonpeptidyl small molecule agonist for GFRalpha-1. Neurochem Int. 2003 Jan;42(1):81-6. DOI:10.1016/s0197-0186(02)00053-0 |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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