| Identification | Back Directory | [Name]
Paramethasone | [CAS]
53-33-8 | [Synonyms]
Cortiden
PARAMETHASONE
16a-Methyl-6a-fluoroprednisolone
6a-Fluoro-16a-methylprednisolone
6-alpha-fluoro-16-alpha-methylprednisolone
6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
6a-fluoro-11b,17a,21-trihydroxy-16a-methyl-1,4-pregnadiene-3,20-dione
Pregna-1,4-diene-3,20-dione, 6a-fluoro-11b,17,21-trihydroxy-16-methyl- (7CI)
1,4-PREGNADIEN-6-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE
Pregna-1,4-diene-3,20-dione, 6a-fluoro-11b,17,21-trihydroxy-16a-methyl- (8CI)
6-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)- (9CI)
(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one | [EINECS(EC#)]
200-169-2 | [Molecular Formula]
C22H29FO5 | [MDL Number]
MFCD03695621 | [MOL File]
53-33-8.mol | [Molecular Weight]
392.46 |
| Chemical Properties | Back Directory | [Melting point ]
228-241°C | [Boiling point ]
573.5±50.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
12.34±0.70(Predicted) | [color ]
White to Pale Beige | [CAS DataBase Reference]
53-33-8 |
| Hazard Information | Back Directory | [Uses]
Glucocorticoid. | [Brand name]
Haldrone (Lilly). | [Originator]
Haldrone,Lilly,US,1961 | [Definition]
ChEBI:Paramethasone is a fluorinated steroid. | [Manufacturing Process]
A solution of 0.144 g of the 3-ethylene glycol ketal of 5α,11β,17α,21 tetrahydroxy-6β-fluoro-16α-methylallopregnane-3,20-dione-21 acetate in 12 ml of chloroform and 0.1 ml of absolute alcohol was cooled to -10°C in an icesalt bath and a stream of anhydrous hydrochloric acid was gently bubbled through the solution for 2.5 hours while the temperature was maintained between -5°C and -15°C. The solution was then diluted with 25 ml of chloroform, washed with dilute sodium bicarbonate and water, dried over anhydrous sodium sulfate, and evaporated to dryness under reduced pressure at 60°C or less to give 6α-fluoro-11β,17α,21-trihydroxy-16α-methyl-4-pregnene3,20-dione 21-acetate.
| [Therapeutic Function]
Glucocorticoid |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Shaanxi Dideu Medichem Co. Ltd
|
| Telephone: |
+86-29-87569266 +86-17392581500 |
| Website: |
https://www.chemicalbook.com/manufacturer/shaanxi-dideu-medichem-220/ |
|