| Identification | Back Directory | [Name]
K 41 | [CAS]
53026-37-2 | [Synonyms]
K 41
37454 RP
Antibiotic K-41A
Antibiotic A 32887
L-xylo-L-manno-α-D-gluco-L-ribo-α-L-gluco-D-glycero-3,13,29-Triacontotriulo-13,16-furanose-3,7:29,25-dipyranosonic acid, 9,13:17,20:21,24-trianhydro-4,8,10,12,14,18,19,22,23,26,28,30-dodecadeoxy-4,12,14,26,28-pentamethyl-6,16-di-C-methyl-5,6,11,15-tetra-O-methyl-27-O-[(2R,5S,6R)-tetrahydro-5-methoxy... | [Molecular Formula]
C48H82O18 | [MDL Number]
MFCD01770000 | [MOL File]
53026-37-2.mol | [Molecular Weight]
947.15 |
| Chemical Properties | Back Directory | [Melting point ]
158-160 °C | [Boiling point ]
913.8±65.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble | [form ]
A solid | [pka]
3.48±0.11(Predicted) |
| Hazard Information | Back Directory | [Uses]
K-41 is an orally active antibiotic. K-41 can be obtained from Streptomyces hygroscopicus. K-41 has antibacterial and antiplasmodial activity[1][2]. | [in vivo]
K-41 (p.o.) inhibits P. berghei and P. yoeliiinfection in mice, with ED50s of 1.9 and 7.0 mg/kg, respectively[1]. | [References]
[1] Otoguro K, et al. In vitro and in vivo antimalarial activities of the monoglycoside polyether antibiotic, K-41 against drug resistant strains of Plasmodia. J Antibiot (Tokyo). 2002 Sep;55(9):832-4. DOI:10.7164/antibiotics.55.832
[2] Tsuji N, et al. Two new antibiotics, A-218 and K-41. Isolation and characterization. J Antibiot (Tokyo). 1976 Jan;29(1):10-4. DOI:10.7164/antibiotics.29.10 |
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