| Identification | Back Directory | [Name]
16-DOXYL-STEARIC ACID | [CAS]
53034-38-1 | [Synonyms]
16NS
16-SASL
16DOXYL
16-Doxy-stearic acid
16-DOXYL-STEARIC ACID
Freeradical(spinlabel)
16-nitroxystearic acid
16-DOXYL-stearic Acid
16-DOXYL-stearicAcidFreeRadical>
16-DOXYL-STEARIC ACID, FREE RADICAL [SPIN LABEL] 92+%
2-(14-CARBOXYTETRADECYL)-2-ETHYL-4,4-DIMETHYL-3-OXAZOLIDINYLOXY
3-Oxazolidinyloxy, 2-(14-carboxytetradecyl)-2-ethyl-4,4-diMethyl-
2-(14-carboxytetradecyl)-2-ethyl-4,4-dimethyl-3-oxazolidinyloxy, free radical
15-(2-ethyl-3-$l^{1}-oxidanyl-4,4-dimethyl-1,3-oxazolidin-2-yl)pentadecanoic acid | [EINECS(EC#)]
251-228-4 | [Molecular Formula]
C22H42NO4 * | [MDL Number]
MFCD00010066 | [MOL File]
53034-38-1.mol | [Molecular Weight]
384.57 |
| Chemical Properties | Back Directory | [Melting point ]
47-55 °C(lit.) | [Fp ]
113 °C | [storage temp. ]
0-6°C | [solubility ]
DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml | [form ]
powder to crystal | [color ]
White to Yellow | [Stability:]
Hygroscopic | [CAS DataBase Reference]
53034-38-1 |
| Hazard Information | Back Directory | [Description]
16-doxyl Stearic acid is a form of stearic acid that contains a 4,4-dimethyl-3-oxazolinyloxy (DOXYL) group, creating a hydrophobic spin label. It is commonly used to study molecular aspects of membranes and hydrophobic proteins. | [Uses]
16-DOXYL-stearic acid, free radical is a spin label for membrane fluidity studies. It can be used to study the dynamics of the lipid bilayer, distribution of fatty acids, and effects of lipid components on detergent-resistant membranes. It can be used for the investigation of surfactant effects on protein formulations by EPR spectroscopic technique. | [Uses]
Involved in membrane studies including:
- Dynamics and state of lipid bilayer-internal water using 1H dynamic nuclear polarization
- Distribution of fatty acids
- Transversal relaxation of nitroxides for PELDOR Spectroscopy
- Effects of different lipid components on detergent-resistant membranes
| [Definition]
ChEBI: 16-DOXYL-stearic acid is a member of aminoxyls. It is functionally related to a 4,4-dimethyloxazolidine-N-oxyl and an octadecanoic acid. | [References]
[1] NATALYA G KORMOSH. Conformational changes in inter-α-trypsin inhibitor heavy chain 4 activate its tumor-specific activity in mice with B16 melanoma.[J]. Molecular medicine reports, 2015: 4483-4493. DOI: 10.3892/mmr.2015.3961
[2] KARINE LAULAGNIER. Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization.[J]. Biochemical Journal, 2004, 380 Pt 1: 161-171. DOI: 10.1042/bj20031594
[3] EKATERINA A. VISHNYAKOVA . Spin-labeling study of membranes in wheat embryo axes. 1. Partitioning of doxyl stearates into the lipid domains[J]. Biochimica et biophysica acta. Biomembranes, 2000, 1467 2: Pages 380-394. DOI: 10.1016/s0005-2736(00)00234-0 |
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