| Identification | Back Directory | [Name]
CYCLO(-HIS-PRO) | [CAS]
53109-32-3 | [Synonyms]
HIS-PRO, CYCLIC
CYCLO(-HIS-PRO)
Cyclo-Pro-His-HO
CYCLO(HIS-PRO), >99%
Cyclo(histidyl-proline)
Protirelin EP Impurity E
Cyclo(L-histidyl-L-proline)
histidylproline dioxopiperazine
Histidylproline diketopiperazine
CYCLO(HISTIDYL-PROLINE); HISTIDYLPROLINE DIKETOPIPERAZINE
(3S,6S)-3-(3H-imidazol-4-ylmethyl)-1,4-diazabicyclo[4.4.0]decane-2,5-dione
Cyclo(his-pro),Cyclo(histidyl-proline),Histidylproline diketopiperazine, >99%
3-(1H-imidazol-5-ylmethyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(1H-imidazol-4-ylmethyl)-, (3S,8aS)- | [Molecular Formula]
C11H14N4O2 | [MDL Number]
MFCD00133207 | [MOL File]
53109-32-3.mol | [Molecular Weight]
234.25 |
| Chemical Properties | Back Directory | [Melting point ]
162-164 °C | [Boiling point ]
659.3±48.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml | [form ]
A neat oil | [pka]
12.73±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Cyclo(L-histidyl-L-proline) is used in the pharmaceutical composition comprising cyclo(His-Pro) for preventing or treating obesity. | [Definition]
ChEBI: Cyclo(L-His-L-Pro) is a homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH). It has a role as a human blood serum metabolite, a dopamine uptake inhibitor and an anti-inflammatory agent. It is a homodetic cyclic peptide, a dipeptide, a pyrrolopyrazine and a member of imidazoles. It is functionally related to a L-histidine and a L-proline. |
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