| Identification | Back Directory | [Name]
Euparin | [CAS]
532-48-9 | [Synonyms]
Euparin
Euparine
EUPARIN(P)
5-Acetyl-2-isopropenylbenzofuran-6-ol
5-Acetyl-6-hydroxy-2-isopropenylbenzofuran
Methyl(2-isopropenyl-6-hydroxybenzofuran-5-yl) ketone
1-(6-hydroxy-2-prop-1-en-2-yl-1-benzofuran-5-yl)ethanone
Ethanone, 1-[6-hydroxy-2-(1-methylethenyl)-5-benzofuranyl]- | [Molecular Formula]
C13H12O3 | [MDL Number]
MFCD00597231 | [MOL File]
532-48-9.mol | [Molecular Weight]
216.23 |
| Chemical Properties | Back Directory | [Melting point ]
152-153℃ | [Boiling point ]
296.65°C (rough estimate) | [density ]
1.2003 (rough estimate) | [refractive index ]
1.4740 (estimate) | [storage temp. ]
Store at -20°C, sealed storage, away from moisture and light | [form ]
Solid | [pka]
9.33±0.40(Predicted) | [color ]
Light yellow to yellow | [LogP]
3.450 (est) |
| Hazard Information | Back Directory | [Uses]
Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects[1][2]. | [Definition]
ChEBI: A natural product found in Eupatorium cannabinum subspecies asiaticum. | [in vivo]
Euparin (8, 16 and 32 mg/kg) reduces depression-like behavior in Chronic Unpredictable Mild Stress (CUMS) model of mice. All doses of Euparin are found to increase the contents of monoamine neurotransmitter and decrease monoamine oxidase and reactive oxygen species (ROS) levels in brain of depression mice. Euparin restores CUMS-induced decrease of Spermidine/Spermine N1-Acetyltransferase 1 (SAT1), N-methyl-D-aspartate receptor subtype 2B (NMDAR2B) and brain derived neurotrophic factor (BDNF) expression[2]. | [References]
[1] aría Florencia Visintini Jaime, et al. Antipoliovirus Activity of the Organic Extract of Eupatorium buniifolium: Isolation of Euparin as an Active Compound. Evid Based Complement Alternat Med. 2013;2013:402364. DOI:10.1155/2013/402364
[2] Xu-Meng Han, et al. Antidepressant Activity of Euparin: Involvement of Monoaminergic Neurotransmitters and SAT1/NMDAR2B/BDNF Signal Pathway. Biol Pharm Bull. 2020 Oct 1;43(10):1490-1500. DOI:10.1248/bpb.b20-00093 |
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| Company Name: |
Shaanxi Dideu Medichem Co. Ltd
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| Telephone: |
+86-29-87569266 +86-17392581500 |
| Website: |
https://www.chemicalbook.com/manufacturer/shaanxi-dideu-medichem-220/ |
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