| Identification | Back Directory | [Name]
N,N-diethyl-N'-(6-methoxy-4-methyl-8-quinolyl)hexane-1,6-diamine dihydrochloride | [CAS]
5330-29-0 | [Synonyms]
WR-006026
N,N-diethyl-N'-(6-methoxy-4-methyl-8-quinolyl)hexane-1,6-diamine dihydrochloride
1,6-Hexanediamine,N1,N1-diethyl-N6-(6-methoxy-4-methyl-8-quinolinyl)-, hydrochloride (1:2) | [EINECS(EC#)]
226-224-0 | [Molecular Formula]
C21H34ClN3O | [MOL File]
5330-29-0.mol | [Molecular Weight]
379.97 |
| Hazard Information | Back Directory | [Uses]
Sitamaquine (WR6026) hydrochloride, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine hydrochloride inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine hydrochloride is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes[1][2]. | [References]
[1] López-Martín C, et al. Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes. Antimicrob Agents Chemother. 2008;52(11):4030-4036. DOI:10.1128/AAC.00964-08
[2] Luis Carvalho, et al. The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase. Antimicrob Agents Chemother. 2011 Sep;55(9):4204-10. DOI:10.1128/AAC.00520-11 |
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