| Identification | Back Directory | [Name]
Cyclopenta[c][1]benzopyran-8-ol, 1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aR,4S,9bS)-rel- | [CAS]
533883-77-1 | [Synonyms]
Cyclopenta[c][1]benzopyran-8-ol, 1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aR,4S,9bS)-rel-
Cyclopenta[c][1]benzopyran8ol, 1,2,3,3a,4,9bhexahydro4(4hydroxyphenyl), (3aR,4S,9bS)rel,Cyclopenta[c][1]benzopyran 8 ol, 1,2,3,3a,4,9b hexahydro 4 (4 hydroxyphenyl) , (3aR,4S,9bS) rel | [Molecular Formula]
C18H18O3 | [MOL File]
533883-77-1.mol | [Molecular Weight]
282.33 |
| Hazard Information | Back Directory | [Uses]
rel-Erteberel is rel isomer of Erteberel (HY-18295). Erteberel is a potent and selective estrogen receptor beta (ERβ) agonist with Ki and EC50 of 1.54 nM and 3.61 nM, respectively. Erteberel has anti-tumor activities[1][2]. | [IC 50]
ERβ: 1.54 nM (IC50); ERβ: 3.61 nM (EC50) | [References]
[1] Zhao L, et al. Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3673-E3681. DOI:10.1073/pnas.1803291115
[2] Sareddy GR, et al. Selective Estrogen Receptor β Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma. Sci Rep. 2016 Apr 29;6:24185. DOI:10.1038/srep24185 |
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