5361-15-9

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5361-15-9 Structure

Identification	Back Directory
[Name] NSC 403387 hydrochloride
[CAS] 5361-15-9
[Synonyms] GMQ hydrochloride NSC 403387 hydrochloride GMQ hydrochloride >=95% (HPLC) 2-GUANIDINO-4-METHYLQUINAZOLINE HYDROCHLORIDE 2-Guanidine-4-methylquinazoline hydrochloride 4-Methyl-2-guanidino quinazoline hydrochloride 1-(4-Methylquinazolin-2-yl)guanidine hydrochloride N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride
[Molecular Formula] C10H12ClN5
[MDL Number] MFCD00035249
[MOL File] 5361-15-9.mol
[Molecular Weight] 237.69

Chemical Properties	Back Directory
[Melting point ] 328-330 °C
[storage temp. ] room temp
[solubility ] DMSO: soluble2mg/mL, clear (warmed)
[form ] powder
[color ] white to beige

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H315-H319-H335
[Precautionary statements ] P261-P264-P271-P280-P302+P352-P305+P351+P338
[Hazard Codes ] Xi
[Risk Statements ] 36/37/38
[Safety Statements ] 26-36
[WGK Germany ] 3

Hazard Information	Back Directory
[Uses] GMQ Hydrochloride is a selective ASIC3 opener.
[Biological Activity] GMQ/2-Guanidine-4-methylquinazoline is a potent and selective modulator of acid-sensing ion channel (ASIC) th at activates ASIC3 channels under neutral pH. GQM blocks acid-induced maximal peak current and alters ASICs pH dependence for activation and inactivation.

Spectrum Detail	Back Directory
[Spectrum Detail] NSC 403387 hydrochloride(5361-15-9)¹HNMR

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