| Identification | Back Directory | [Name]
Ribostamycin sulfate | [CAS]
53797-35-6 | [Synonyms]
Ibistacin
ribomycine
ribostamin
Mandamycine
landamycine
Ribostamycin s
Vistamycin sulfate
riboflavinesulfate
Ribostamycinesulfate
Ribostamycin sulfate
Rribostamycin sulfate
sf733antibioicsulfate
Ribose neoMycin sulfate
DTDP-GLUCOSE, DISODIUM SALT
Ribostamycin sulfate USP/EP/BP
SPECTINOMYCIN HCL ( VETERINARY)
o-2,6-diamino-2,6-dideoxy-alpha-d-glucopyranosyl-(1-4)-o-(beta-d-streptamin
D-Streptamine, O-2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)-O-[β-D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (1:1)
D-Streptamine, O-2,6-diamino-2,6-dideoxy-a-D-glucopyranosyl-(14)-O-[b-D-ribofuranosyl-(15)]-2-deoxy-, sulfate (salt) (9CI) | [EINECS(EC#)]
258-783-1 | [Molecular Formula]
C17H22N4O10S | [MDL Number]
MFCD02264592 | [MOL File]
53797-35-6.mol | [Molecular Weight]
474.442 |
| Chemical Properties | Back Directory | [Melting point ]
175-180 C | [alpha ]
D20 +39° (c = 1) | [Fp ]
>110°(230°F) | [storage temp. ]
2-8°C
| [solubility ]
H2O: soluble50mg/mL | [form ]
powder | [color ]
White to Off-White | [Water Solubility ]
Soluble in water | [Merck ]
14,8206 | [Stability:]
Hygroscopic | [InChIKey]
RTCDDYYZMGGHOE-CARKYZAMNA-N | [SMILES]
OS(O)(=O)=O.NC[C@@H]1O[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O)[C@@H]2O[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)[C@@H](N)[C@H](O)[C@H]1O |
| Hazard Information | Back Directory | [Uses]
Antibacterial;Ribosomal protein synthesis inhibitor | [Definition]
ChEBI: An aminoglycoside sulfate salt resulting from the reaction of ribostamycin with sulfuric acid. | [Biological Activity]
Aminoglycosidessuch as ribostamycinbind to the bacterial 30S and 50S ribosomal subunitwhich inhibits the translocation of the peptidyl-tRNA from the A-site to the P-site. This causes misreading of mRNA which makes bacteria unable to make essential proteins. It also inhibits the chaperone activity of protein disulfide isomerase (PDI). | [Synthesis]
Preparation of high-purity ribostamycin sulfate:
1. The resolving solution is acidified and diluted.
2. Loaded onto an ion-exchange column, washed with water.
3. Eluted with ammonia, collecting fractions before optical rotation reaches "0".
4. |
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