| Identification | Back Directory | [Name]
Desoxo-narchinol A | [CAS]
53859-06-6 | [Synonyms]
Desoxo-narchinol A
1(4H)-Naphthalenone, 4a,5,6,7-tetrahydro-4-hydroxy-4a,5-dimethyl-, (4R,4aS,5R)- | [Molecular Formula]
C12H16O2 | [MOL File]
53859-06-6.mol | [Molecular Weight]
192.25 |
| Hazard Information | Back Directory | [Uses]
Desoxo-narchinol A is an orally active and potent anti-inflammatory agent. Desoxo-narchinol A can be isolated from the roots and rhizomes of Nardostachys jatamansi. Desoxo-narchinol A can be used for septic shock and inflammatory diseases research[1][2][3]. | [in vivo]
Desoxo-narchinol A (0-0.5 mg/kg, IP, once) dramatically reduced mortality in a murine LPS-induced endotoxin shock model[2].
Desoxo-narchinol A (50 mg/kg, PO, once) shows the oral bioavailability of 18.1% in rats and 28.4% in mice[3] | [References]
[1] Itokawa H, et al. Cytotoxic sesquiterpenes from Nardostachys chinensis. Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1183-4. DOI:10.1248/cpb.41.1183
[2] Shin JY, et al. Anti-inflammatory effect of desoxo-narchinol-A isolated from Nardostachys jatamansi against lipopolysaccharide. Int Immunopharmacol. 2015 Dec;29(2):730-738. DOI:10.1016/j.intimp.2015.09.002
[3] Thapa SK, Upadhyay M, Kim TH, Shin S, Park SJ, Shin BS. Liquid Chromatography-Tandem Mass Spectrometry of Desoxo-Narchinol a and Its Pharmacokinetics and Oral Bioavailability in Rats and Mice. Molecules. 2019 May 28;24(11):2037. DOI:10.3390/molecules24112037 |
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