| Identification | Back Directory | [Name]
PNU-37802 | [CAS]
5397-78-4 | [Synonyms]
NSC4264
NSC-4264
NSC 4264
PNU-37802
2-ACETAMIDO-3-CHLORO-1,4-NAPHTHOQUINONE
N-(1,4-Dihydro-3-chloro-1,4-dioxonaphthalen-2-yl)acetamide
N-(1,4-Dioxo-3-chloro-1,4-dihydronaphthalene-2-yl)acetamide | [Molecular Formula]
C12H8ClNO3 | [MDL Number]
MFCD00091844 | [MOL File]
5397-78-4.mol | [Molecular Weight]
249.65 |
| Chemical Properties | Back Directory | [Melting point ]
219 °C | [Boiling point ]
427.7±45.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.30±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
NP-313 is an antithrombotic agent with dual inhibition of thromboxane A2 synthesis and calcium entry. | [Uses]
NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca2+ inward flow[1]. | [in vivo]
NP-313 (i.v., 4-16 μg/g) significantly prolongs occlusion time (TTO), prolongs bleeding time and inhibits platelet aggregation induced by collagen (10 μg/mL) in male ICR mice[1].
| [References]
[1] Heng-Lan Kuo, et al. NP-313, 2-acetylamino-3-chloro-1,4-naphthoquinone, a novel antithrombotic agent with dual inhibition of thromboxane A(2) synthesis and calcium entry. Br J Pharmacol. 2011 Apr;162(8):1871-83. DOI:10.1111/j.1476-5381.2011.01200.x |
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Sigma-Aldrich
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Merck KGaA
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www.sigmaaldrich.cn |
| Company Name: |
Specs
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