| Identification | Back Directory | [Name]
Ricinelaidicacid | [CAS]
540-12-5 | [Synonyms]
9-trans-12-Hydroxyoctadecenoic acid
(12R,9E)-12-Hydroxy-9-octadecenoic acid
9-Octadecenoic acid, 12-hydroxy-, (9E,12R)- | [Molecular Formula]
C18H34O3 | [MOL File]
540-12-5.mol | [Molecular Weight]
298.46 |
| Chemical Properties | Back Directory | [Melting point ]
51～52 1) | [refractive index ]
－ | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: miscible; PBS (pH 7.2): 2 mg/ml |
| Hazard Information | Back Directory | [Uses]
Ricinelaidic acid, a 12-hydroxy fatty acid，is a leukotriene B4 (LTB4) receptor antagonist with the Ki of 2 μM in porcine neutrophil membranes. Ricinelaidic acid inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neutrophils (IC50=10 and 7 μM, respectively). Ricinelaidic acid inhibits bronchoconstriction induced by LTB4 in rats[1]. | [Definition]
ChEBI: A straight-chain, 18:1, long-chain fatty acid having a trans- double bond at position 9 and an R-oriented hydroxy group at position 12. | [storage]
Store at -20°C | [References]
[1] Yagaloff KA, et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot Essent Fatty Acids. 1995;52(5):293-297. DOI:10.1016/0952-3278(95)90029-2 |
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