| Identification | Back Directory | [Name]
Fluclotizolam | [CAS]
54123-15-8 | [Synonyms]
2-chloro-4-(2-fluoro-phenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine | [EINECS(EC#)]
200-284-8 | [Molecular Formula]
C15H10ClFN4S | [MOL File]
54123-15-8.mol | [Molecular Weight]
332.78 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMF: 5 mg/ml DMSO: 5 mg/ml DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid | [λmax]
241 nm | [InChI]
InChI=1S/C15H10ClFN4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)17)10-6-12(16)22-15(10)21(8)13/h2-6H,7H2,1H3 | [InChIKey]
ZDYRCUZZLRLMHG-UHFFFAOYSA-N | [SMILES]
N12C(C)=NN=C1CN=C(C1=CC=CC=C1F)C1C=C(Cl)SC=12 |
| Hazard Information | Back Directory | [Description]
Fluclotizolam (54123-15-8) is an analytical reference standard categorized as a thienotriazolodiazepine.1 This product is intended for research and forensic applications. | [Chemical Properties]
Flualprazolam (8-chloro-6-(2-fluorophenyl)-1-methyl-4H- [1,2,4]triazolo[4,3-a][1,4]benzodiazepine) is a triazolobenzodiazepine and is structurally similar to alprazolam. Flualprazolam is composed of a benzene ring fused to a seven-membered 1,4- diazepine ring. Flualprazolam also contains a fused triazolo ring. A methyl (-CH3) group is attached at the 1-position, a 2- fluorophenyl ring is attached at the 6-position, and a chlorine is attached at the 8-position of the triazolobenzodiazepine structure. Flualprazolam has a molecular formula of C17H12ClFN4 and a molecular weight of 326.76 g/mol. | [History]
Fluclotizolam is a thienotriazolodiazepine derivative which was first synthesised in 1979, but was never marketed. It has subsequently been sold as a designer drug, first being definitively identified in 2017. | [Uses]
Fluclotizolam is one of the New Psychoactive Substancces (NPS). | [Side effects]
Fluclotizolam produces a sedative-hypnotic effect, often causing drowsiness, muscle relaxation and slowed, sluggish reactions.
| [Regulatory Status]
Flualprazolam is not currently controlled under the Controlled Substances Act. At the 2020 Commission on Narcotic Drugs Sixty-third session, the Commission decided to include flualprazolam in Schedule IV of the 1971 Convention on Psychotropic Substance.
https://www.deadiversion.usdoj.gov
https://www.federalregister.gov | [References]
1. Moosmann, B., and Auw?rter, V. New Psychoactive Substances. Handbook of Experimental Pharmacology. Designer benzodiazepines: Another class of new psychoactive substances 252, 383-410 (2018). |
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