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541547-35-7

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541547-35-7 Structure

541547-35-7 Structure
IdentificationBack Directory
[Name]

Agatolimod sodium
[CAS]

541547-35-7
[Synonyms]

CpG2006
Agatolimod sodium
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
[Sequence]

DNA, d(P-thio)(T-C-G-T-C-G-T-T-T-T-G-T-C-G-T-T-T-T-G-T-C-G-T-T)
Hazard InformationBack Directory
[Uses]

Agatolimod sodium (ODN 2006) is a class B CpG ODN and is a TLR9 agonist. Agatolimod sodium can be used as vaccine adjuvant. Agatolimod sodium can be used for the research of cancer. Sequence: 5’-TCGTCGTTTTGTCGTTTTGTCGTT-3’[1][2].
[IC 50]

TLR9
[References]

[1] Yan L, et al. CpG-ODN 7909 increases radiation sensitivity of radiation-resistant human lung adenocarcinoma cell line by overexpression of Toll-like receptor 9. Cancer Biother Radiopharm. 2013 Sep;28(7):559-64. DOI:10.1089/cbr.2012.1450
[2] Cooper CL, et al. Safety and immunogenicity of CPG 7909 injection as an adjuvant to Fluarix influenza vaccine. Vaccine. 2004 Aug 13;22(23-24):3136-43. DOI:10.1016/j.vaccine.2004.01.058
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