| Identification | Back Directory | [Name]
3,4-DIMETHOXYCHALCONE | [CAS]
5416-71-7 | [Synonyms]
AKOS 220-38
3,4-DIMETHOXYCHALCONE
LABOTEST-BB LT00454345
DIMETHOXYCHALCONE,3,4-
3-(3,4-DIMETHOXYPHENYL)-1-PHENYLPROP-2-EN-1-ONE
2-Propen-1-one, 3-(3,4-dimethoxyphenyl)-1-phenyl-
(E)-3-(3,4-DIMETHOXYPHENYL)-1-PHENYLPROP-2-EN-1-ONE | [Molecular Formula]
C17H16O3 | [MDL Number]
MFCD00041327 | [MOL File]
5416-71-7.mol | [Molecular Weight]
268.31 |
| Chemical Properties | Back Directory | [Melting point ]
88°C | [Boiling point ]
421.8±45.0 °C(Predicted) | [density ]
1.128±0.06 g/cm3(Predicted) | [form ]
Solid | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Uses]
3,4-Dimethoxychalcone is a Caloric restriction mimetics (CRMs). 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research[1]. | [in vivo]
3,4-Dimethoxychalcone (230 mg/kg for intraperitoneal injection) induces the nuclear translocation of TFEB and TFE3 of liver and heart tissues in Female C57/BL6 mice[1].
| [References]
[1] Okolo EN, et al. New chalcone derivatives as potential antimicrobial and antioxidant agent. Sci Rep. 2021 Nov 5;11(1):21781. DOI:10.1038/s41598-021-01292-5
[2] Chen G, et al. 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Mol Med. 2019 Nov 7;11(11):e10469. DOI:10.15252/emmm.201910469 |
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