| Identification | Back Directory | [Name]
6-BROMO-2-METHYL-3,4-DIHYDROQUINAZOLIN-4-ONE | [CAS]
5426-59-5 | [Synonyms]
6-broMo-2-Methylquinazolin-4-ol
6-bromo-2-methylquinazolin-4(1H)-one
6-bromo-2-methyl-4(3H)-Quinazolinone
6-bromo-2-methyl-1H-quinazolin-4-one
4(1H)-Quinazolinone, 6-bromo-2-methyl-
4(3H)-Quinazolinone, 6-bromo-2-methyl-
6-BROMO-2-METHYL-3,4-DIHYDROQUINAZOLIN-4-ONE
6-bromo-2-methylquinazolin-4(3H)-one(SALTDATA: FREE) | [Molecular Formula]
C9H7BrN2O | [MDL Number]
MFCD00548197 | [MOL File]
5426-59-5.mol | [Molecular Weight]
239.07 |
| Chemical Properties | Back Directory | [Melting point ]
298 °C | [Boiling point ]
372.6±44.0 °C(Predicted) | [density ]
1.72±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
1.96±0.20(Predicted) | [Appearance]
Off-white to light brown Solid |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow solid | [Synthesis]
The general procedure for the synthesis of 6-bromo-2-methylquinazolin-4(3H)-one from ethanoic anhydride and 2-amino-5-bromobenzoic acid was as follows: first, 2-amino-5-bromobenzoic acid was refluxed for 1 h in liquid ammonia (10 mL/g). Subsequently, the reaction solution was concentrated to a smaller volume and the residue was mixed with acetic anhydride (2 mL/g) and refluxing was continued for 4 hours. Upon completion of the reaction, water was added to the mixture and boiled for 30 minutes, followed by dropwise addition of 20% sodium hydroxide solution until a clarified solution was formed. Next, ammonium carbonate was added to the hot solution until a precipitate was formed. The mixture was allowed to stand at 4°C for 16 hours, after which the precipitate was collected by filtration, washed with water and finally dried under vacuum to give the target product in about 60% yield. | [References]
[1] Patent: US2009/69320, 2009, A1. Location in patent: Page/Page column 76
[2] Journal of the American Chemical Society, 1906, vol. 28, p. 101 |
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