| Identification | Back Directory | [Name]
N-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]pyrazine-2-carboxamide | [CAS]
544416-00-4 | [Synonyms]
WAY-324546
N-(4-(2,4-Dimethylphenyl)thiazol-2-yl)pyrazine-2-carboxamide
2-Pyrazinecarboxamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]-
N-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]pyrazine-2-carboxamide | [Molecular Formula]
C16H14N4OS | [MDL Number]
MFCD03376422 | [MOL File]
544416-00-4.mol | [Molecular Weight]
310.37 |
| Chemical Properties | Back Directory | [Melting point ]
168.5-169.5 °C | [density ]
1.319±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
5.46±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Nek2/Hec1-IN-2 (Compound 14) is an inhibitor of Nek2/Hec1. Nek2/Hec1-IN-2 inhibits cancer cell proliferation with IC50 >25 μM[1]. | [IC 50]
NEK2 | [References]
[1] Qiu XL, et al. Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J Med Chem. 2009 Mar 26;52(6):1757-67. DOI:10.1021/jm8015969 |
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