| Identification | Back Directory | [Name]
MRS 1845 | [CAS]
544478-19-5 | [Synonyms]
MRS 1845
N-PROPARGYLNITRENDIPENE
MRS-1845;MRS1845;MRS 1845
MRS 1845 >=95% (HPLC), solid
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propynyl)-3,5-pyridinedicarboxylicacidethylmethylester
1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-1-(2-PROPYNYL)-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL, METHYL ESTER
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propyn-1-yl)-, 3-ethyl 5-methyl ester | [Molecular Formula]
C21H22N2O6 | [MDL Number]
MFCD06798381 | [MOL File]
544478-19-5.mol | [Molecular Weight]
398.41 |
| Chemical Properties | Back Directory | [Boiling point ]
511.0±50.0 °C(Predicted) | [density ]
1.238±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
DMSO: 13 mg/mL at 60 °C, soluble
| [form ]
solid
| [pka]
0.03±0.70(Predicted) | [color ]
yellow
|
| Hazard Information | Back Directory | [Uses]
MRS 1845 acts as a potent SOCE inhibitor that can block Ca2+ capacitative entry resulting in an antiinflammatory effect. | [Biological Activity]
Potent blocker of store-operated Ca 2+ channels; inhibits capacitative Ca 2+ influx in HL-60 cells (IC 50 = 1.7 mM). |
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