| Identification | Back Directory | [Name]
N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide | [CAS]
544681-96-1 | [Synonyms]
GATA4-IN-3
GATA4-NKX2-5-IN-1
GATA4-IN-3
(GATA4 inhibitor 3)
N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide
N-[4-(Diethylamino)phenyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide | [Molecular Formula]
C21H23N3O2 | [MDL Number]
MFCD03382728 | [MOL File]
544681-96-1.mol | [Molecular Weight]
349.43 |
| Chemical Properties | Back Directory | [Boiling point ]
486.6±45.0 °C(Predicted) | [density ]
1.176±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 70 mg/mL (200.33 mM);Ethanol: 9 mg/mL (25.76 mM) | [form ]
Solid | [pka]
11.56±0.70(Predicted) | [color ]
Off-white to pale purple | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Uses]
GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression[1]. | [References]
[1] V?lim?ki MJ, et al. Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5. J Med Chem. 2017 Sep 28;60(18):7781-7798. DOI:10.1021/acs.jmedchem.7b00816 |
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