| Identification | Back Directory | [Name]
JNJ 10181457 dihydrochloride | [CAS]
544707-19-9 | [Synonyms]
JNJ 10181457
JNJ 10181457 dihydrochloride
4-[[3-(4-piperidin-1-ylbut-1-ynyl)phenyl]methyl]morpholine
Morpholine, 4-[[3-[4-(1-piperidinyl)-1-butyn-1-yl]phenyl]methyl]- | [Molecular Formula]
C20H28N2O | [MDL Number]
MFCD19690930 | [MOL File]
544707-19-9.mol | [Molecular Weight]
312.45 |
| Chemical Properties | Back Directory | [Boiling point ]
452.7±45.0 °C(predicted) | [density ]
1.10±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [storage temp. ]
Desiccate at RT | [solubility ]
Soluble in DMSO | [pka]
8.69±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
JNJ 10181457 Dihydrochloride is an inhibitor of the histamine H3 receptor. | [Uses]
JNJ 10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmission. | [in vivo]
JNJ 10181457 (1 mg/kg, i.v.) can completely block the inhibition of the vagally induced bradycardic responses produced by histamine (50?μg/kg) or methimepip (50?μg/kg) compared with saline control in male Wistar rats[1].
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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