| Identification | Back Directory | [Name]
4-Benzo[b]thien-2-ylbenzenamine | [CAS]
54492-95-4 | [Synonyms]
4-(1-Benzothien-2-yl)Aniline
4-Benzo[b]thien-2-ylbenzenamine
Benzenamine, 4-benzo[b]thien-2-yl- | [Molecular Formula]
C14H11NS | [MDL Number]
MFCD14636565 | [MOL File]
54492-95-4.mol | [Molecular Weight]
225.31 |
| Chemical Properties | Back Directory | [InChI]
InChI=1S/C14H11NS/c15-12-7-5-10(6-8-12)14-9-11-3-1-2-4-13(11)16-14/h1-9H,15H2 | [InChIKey]
KCZKJUGTTGALLE-UHFFFAOYSA-N | [SMILES]
C1(N)=CC=C(C2SC3=CC=CC=C3C=2)C=C1 |
| Hazard Information | Back Directory | [Uses]
Used as a pharmaceutical intermediate for laboratory research. | [Synthesis]
4-Benzo[b]thiophen-2-yl-phenylamine was prepared according to the following procedure. A mixture of 4-iodoaniline (2.5 g, 11.2 mmol), 2-benzothio-pheneboronic acid (2.0 g, 11.2 mmol) and sodium carbonate (1.2 g, 11.2 mmol) in toluene (60 mL), ethanol (10 mL) and water (1 mL) was degassed with nitrogen for 5 min. A catalytic amount of Pd(dppf)2Cl2 was added, and the mixture was heated to reflux for 3 h. The mixture was cooled, adsorbed onto silica gel and purified by flash chromatography, 4-benzo[b]thiophen-2-yl-phenylamine.
![4-Benzo[b]thien-2-ylbenzenamine synthesis](/NewsImg/2023-05-30/6382106378916897303984555.png "4-Benzo[b]thien-2-ylbenzenamine synthesis") |
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