| Identification | Back Directory | [Name]
2-(2-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | [CAS]
5466-11-5 | [Synonyms]
2-Chloro-6-deaminoadenosine
2-Chloro-6-deazaminoadenosine
2-Chloro-9-(b-D-ribofuranosyl)purine
2-Chloro-9-(beta-D-ribofuranosyl)purine
9H-Purine, 2-chloro-9-β-D-ribofuranosyl-
2-(2-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3R,4S,5R)-2-(2-Chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | [Molecular Formula]
C10H11ClN4O4 | [MDL Number]
MFCD28334662 | [MOL File]
5466-11-5.mol | [Molecular Weight]
286.67 |
| Chemical Properties | Back Directory | [Melting point ]
154-156 °C(Solv: water (7732-18-5)) | [Boiling point ]
580.9±60.0 °C(Predicted) | [density ]
2.03±0.1 g/cm3(Predicted) | [pka]
13.07±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
2-Chloro-9-(beta-D-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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