| Identification | Back Directory | [Name]
20-DEOXYINGENOL | [CAS]
54706-99-9 | [Synonyms]
20-DEOXYINGENOL
20-Deoxyingenol, >98%
20-deoxyingenol 54706-99-9
(1aR,10aα)-1a,2,5,5a,6,9,10,10a-Octahydro-5β,5aβ,6β-trihydroxy-1,1,4,7,9α-pentamethyl-1H-2α,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one
1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one, 1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-1,1,4,7,9-pentamethyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)- | [EINECS(EC#)]
2017-001-1 | [Molecular Formula]
C20H28O4 | [MDL Number]
MFCD30207875 | [MOL File]
54706-99-9.mol | [Molecular Weight]
332.43 |
| Chemical Properties | Back Directory | [Melting point ]
208-209℃ (分解) | [Boiling point ]
470.5±45.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (150.41 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | [form ]
Powder | [pka]
12.21±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
20-Deoxyingenol is a diterpene derivative of Ingenol (I655795), the analogue of Ingenol 3-Angelate (I655800), which has anti-tumor activity when used topically for the treatment of actinic keratosis. | [in vivo]
20-Deoxyingenol (20 mg/kg/d; i.p. for 8 weeks) alleviates the progression of OA in the DMM model in mice[2]. | Animal Model: | 10-week-old C57BL/6 male wild-type (WT) mice with destabilization of the medial meniscus (DMM)[2] | | Dosage: | 20 mg/kg | | Administration: | I.p. one time per day, for eight consecutive weeks | | Result: | Had a slightly wider joint space and reduced bone density and calcification compared with the DMM group.
Inhibited the decrease in the thickness of hyaline cartilage (HC), and alleviated the disorder and hypertrophy of chondrocytes in the joint tissues of mice after DMM surgery.
Had less erosion on the surface of the articular cartilage and more proteoglycan content.
Had more positive staining points of LAMP1 and LC3 II, and less cleaved-caspase3 and P16INK4a.
Increased the nuclear level of TFEB.
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| [storage]
Store at -20°C |
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