| Identification | Back Directory | [Name]
Clovoxamine | [CAS]
54739-19-4 | [Synonyms]
DU-13811
DU-23811
Clovoxamine
(E)-1-(4-Chlorophenyl)-5-methoxy-1-pentanone O-(2-aminoethyl)oxime
5-Methoxy-1-(4-chlorophenyl)pentan-1-one (E)-O-(2-aminoethyl)oxime
1-Pentanone, 1-(4-chlorophenyl)-5-methoxy-, O-(2-aminoethyl)oxime, (1E)- | [Molecular Formula]
C14H21ClN2O2 | [MDL Number]
MFCD01709183 | [MOL File]
54739-19-4.mol | [Molecular Weight]
284.78 |
| Hazard Information | Back Directory | [Uses]
Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant[1][2][3]. | [Definition]
ChEBI: Clovoxamine is a 5-methoxyvalerophenone O-(2-aminoethyl)oxime and a member of monochlorobenzenes. It has a role as an antidepressant. | [References]
[1] Staroń J, et al. Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands - Fluoxetine and fluvoxamine. Eur J Med Chem. 2021 Aug 5;220:113533. DOI:10.1016/j.ejmech.2021.113533
[2] Saletu B, et al. Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting antidepressants: quantitative EEG, psychometric and pharmacokinetic studies in man. J Neural Transm. 1980;49(1-2):63-86. DOI:10.1007/BF01249190
[3] de Jong GJ. The use of a pre-column for the direct high-performance liquid chromatographic determination of the anti-depressants clovoxamine and fluvoxamine in plasma. J Chromatogr. 1980 Aug 8;183(2):203-11. DOI:10.1016/s0378-4347(00)81694-1 |
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