| Identification | Back Directory | [Name]
L-PHENYLALANINE-2-D1 | [CAS]
54793-54-3 | [Synonyms]
L-Phenylalanine-d
L-PHENYLALANINE-2-D1 | [Molecular Formula]
C9H10DNO2 | [MDL Number]
MFCD01075438 | [MOL File]
54793-54-3.mol | [Molecular Weight]
166.2 |
| Chemical Properties | Back Directory | [Melting point ]
270-275°C (dec.) (lit.) | [Boiling point ]
307.500±30.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.202±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
solid | [pka]
2.210±0.10(predicted) | [Optical Rotation]
[α]25/D -33.0°, c =1 in H2O | [InChI]
1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1/i8D | [InChIKey]
COLNVLDHVKWLRT-ZXEPEWCSSA-N | [SMILES]
[2H][C@](N)(Cc1ccccc1)C(O)=O | [CAS Number Unlabeled]
63-91-2 |
| Hazard Information | Back Directory | [Uses]
L-Phenylalanine-d is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4]. | [IC 50]
NMDA Receptor | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110 |
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