| Identification | Back Directory | [Name]
protohypericin | [CAS]
548-03-8 | [Synonyms]
protohypericin
1,3,4,6,8,15-Hexahydroxy-10,13-dimethyldibenzo[a,o]perylene-7,16-dione
Dibenzo[a,o]perylene-7,16-dione, 1,3,4,6,8,15-hexahydroxy-10,13-dimethyl- | [Molecular Formula]
C30H18O8 | [MDL Number]
MFCD00210547 | [MOL File]
548-03-8.mol | [Molecular Weight]
506.46 |
| Chemical Properties | Back Directory | [Boiling point ]
954.3±65.0 °C(Predicted) | [density ]
1.736±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
5.63±0.20(Predicted) | [color ]
Purple to black | [LogP]
8.870 (est) |
| Hazard Information | Back Directory | [Uses]
Protohypericin is a naturally occurring naphthodianthrone derived from plant Hypericum perforatum. Radioiodinated protohypericin is used in Tumor necrosis targeted radiotherapy[1][2]. | [References]
[1] Baugh SF. Simultaneous determination of protopseudohypericin, pseudohypericin, protohypericin, and hypericin without light exposure. J AOAC Int. 2005 Nov-Dec;88(6):1607-12. PMID:16526439
[2] Liu X, et al. Tumor necrosis targeted radiotherapy of non-small cell lung cancer using radioiodinated protohypericin in a mouse model. Oncotarget. 2015 Sep 22;6(28):26400-10. DOI:10.18632/oncotarget.4568 |
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