| Identification | Back Directory | [Name]
Mitonafide | [CAS]
54824-17-8 | [Synonyms]
Nsc300288
Aids070527
Mitonafide
Aids-070527
M-4212【pharmaceutical】
N-(2-(Dimethylamino)ethyl)-3-nitronaphthalimide
3-Nitro-N-(2-dimethylaminoethyl)-1,8-naphthalimide
2-[2-(Dimethylamino)ethyl]-5-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione
2-[2-(Dimethylamino)ethyl]-5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione
1H-Benz[de]isoquinoline-1,3 (2H)-dione, 2-[2-(dimethylamino)ethyl]-5-nitro- | [Molecular Formula]
C16H15N3O4 | [MDL Number]
MFCD00866509 | [MOL File]
54824-17-8.mol | [Molecular Weight]
313.31 |
| Chemical Properties | Back Directory | [Melting point ]
138-139 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
496.8±30.0 °C(Predicted) | [density ]
1.384±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
8.76±0.28(Predicted) | [color ]
Brown |
| Hazard Information | Back Directory | [Uses]
A Naphthalimides with potent anticancer activity. | [in vivo]
Mitonafide (0.5 and 1 mg/kg, i.p., 1-7 days) shows antitumoral potency in S-180 bearing mice[4].
Mitonafide (5 mg/kg, i.p., twice a day) shows anticancer activity in HepG2 xenograft model[6].
Mitonafide (single i.p. injection, S-180 bearing mice) shows the LD50 value of 10.0 mg/kg[5].
| Animal Model: | S-180 bearing mice[4] | | Dosage: | 0.5 mg/kg and 1 mg/kg | | Administration: | Intraperitoneal injection (i.p.) for 1-7 days | | Result: | Increased in median survival times. |
| Animal Model: | HepG2 xenograft model [6] | | Dosage: | 5 mg/kg | | Administration: | Intraperitoneal injection (i.p.), twice a day. | | Result: | Exhibited a relative tumor increment rates (T/C) value of 28.8%. |
| [storage]
Store at -20°C |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Synchem OHG
|
| Tel: |
+49 5662 408730 |
| Website: |
www.synchem.de |
|