| Identification | Back Directory | [Name]
NUTLIN-3 | [CAS]
548472-68-0 | [Synonyms]
CS-390
NUTLIN-3
(?)-NUTLIN-3
Nutlin-3, >=98%
NUTLIN3;NUTLIN 3
Nutlin-3 ((±
NUTLIN-3 (Free base)
MDM2 Antagonist, Nutlin-3, Racemic
MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem
4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbony
4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
4-[4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-Methoxy-phenyl)-4,5-dihydro-iMidazole-1-carbonyl]-piperazin-2-one
(+/-)-4-[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE
Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-
2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel- | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C30H30Cl2N4O4 | [MDL Number]
MFCD07784509 | [MOL File]
548472-68-0.mol | [Molecular Weight]
581.49 |
| Chemical Properties | Back Directory | [Melting point ]
>132oC (dec.) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 20 mg/mL, soluble
| [form ]
solid
| [pka]
14.35±0.20(Predicted) | [color ]
White | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. | [InChIKey]
BDUHCSBCVGXTJM-UHFFFAOYSA-N | [SMILES]
N1CCN(C(N2C(C3=CC=C(OC)C=C3OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]2C2=CC=C(Cl)C=C2)=O)CC1=O |&1:20,28,r| |
| Hazard Information | Back Directory | [Description]
(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (−)-nutlin-3 (Item No. 18585) and its less active enantiomer (+)-nutlin-3 (Item No. 10009816).1 In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model. | [Uses]
(+/-)-Nutlin-3 is a small molecule MDM2 antagonist. | [Definition]
ChEBI: 4-[[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone is a stilbenoid. | [reaction suitability]
reagent type: ligand | [Biochem/physiol Actions]
Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73. | [storage]
Store at -20°C | [References]
1) Vassilev et al. (2004), In vivo activation of the p53 pathway by small-molecule antagonists of MDM2; Science, 303 844
2) Ghassemifar et al. (2012), MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells; Neurosci. Lett., 513 106
3) Manfe et al. (2012), MDM2 inhibitor nutlin-3 induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53; J. Invest. Dermatol., 132 1487
4) Kunkele et al. (2012), Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas; Neuro. Oncol., 14 859 |
|
| Company Name: |
NCE Biomedical Co.,Ltd.
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| Telephone: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
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www.chemicalbook.com/ShowSupplierProductsList15748/0_EN.htm |
| Company Name: |
DKMbiochem.Co. Ltd
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| Telephone: |
15901859516 |
| Website: |
http://www.dkmbiochem.com/ |
| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
SPIRO PHARMA
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www.spiropharma.com.cn |
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