| Identification | Back Directory | [Name]
Methanone, [2-(4-morpholinyl)-4-phenyl-5-thiazolyl]phenyl- | [CAS]
55040-82-9 | [Synonyms]
WAY-605462
5-LOX-IN-1
(2-Morpholino-4-phenylthiazol-5-yl)(phenyl)methanone
Methanone, [2-(4-morpholinyl)-4-phenyl-5-thiazolyl]phenyl- | [Molecular Formula]
C20H18N2O2S | [MOL File]
55040-82-9.mol | [Molecular Weight]
350.43 |
| Hazard Information | Back Directory | [Description]
IC50: 2.3 μM (5-LOX)[1] 5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation[1]. 5-LOX-IN-1 (0-10 μM) inhibits 5-LOX with an IC50 value of 2.3 μM[1]. | [Uses]
5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation[1]. | [References]
[1] Sinha S, et al. Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase. Eur J Med Chem. 2018 Oct 5;158:34-50. DOI:10.1016/j.ejmech.2018.08.098 |
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