| Identification | Back Directory | [Name]
NEOBAICALEIN | [CAS]
55084-08-7 | [Synonyms]
NEOBAICALEIN
Skullcapflavon II
Skullcapflavone Ⅱ
scullcapflavone II
SKULLCAPFLAVONE II
Skullcapflavone II >=90% (LC/MS-UV)
2',5-Dihydroxy-6,6',7,8-tetramethoxyflavone
4H-1-Benzopyran-4-one, 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy- | [Molecular Formula]
C19H18O8 | [MDL Number]
MFCD02258879 | [MOL File]
55084-08-7.mol | [Molecular Weight]
374.34 |
| Chemical Properties | Back Directory | [Boiling point ]
636.9±55.0 °C(Predicted) | [density ]
1.375±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
6.81±0.40(Predicted) | [color ]
Yellow | [Major Application]
metabolomics
vitamins, nutraceuticals, and natural products | [InChI]
InChI=1S/C19H18O8/c1-23-11-7-5-6-9(20)13(11)12-8-10(21)14-15(22)17(24-2)19(26-4)18(25-3)16(14)27-12/h5-8,20,22H,1-4H3 | [InChIKey]
GMQFOKBGMKVUQZ-UHFFFAOYSA-N | [SMILES]
C1(C2=C(OC)C=CC=C2O)OC2=C(OC)C(OC)=C(OC)C(O)=C2C(=O)C=1 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Schisandra chinensis. | [Uses]
Skullcapflavone II is derived from Scutellaria baicalensis, inhibitis ovalbumin-induced airway inflammation in a mouse model of asthma. | [Definition]
ChEBI: A tetramethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7, 8 and 6' and hydroxy groups at positons 5 and 2' respectively. | [in vivo]
Skullcapflavone II, a potential bradykinin antagonist, reduces the major pathophysiological features of allergic asthma, at least in part by acting on TGF-β1/Smad signaling pathways[3]. | [target]
TGF-β/Smad | COX |
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